La historia de esta serie se centra en Nick Castle (Nathan Fillion), un exitoso escritor de novela negra que termina trabajando al lado de la inspectora de policía Kate Beckett (Stana Katia) para atrapar a un asesino en serie que reproduce los escenarios del famoso escritor.

El elenco de la temporada 2	Stana Katic - Detective Kate Beckett	Stana Katic - Detective Kate Beckett
Stana Katic - Detective Kate Beckett	Stana Katic - Detective Kate Beckett	Stana Katic - Detective Kate Beckett
Stana Katic - Detective Kate Beckett	Stana Katic - Detective Kate Beckett	Nathan Fillion - Richard Castle
Nathan Fillion - Richard Castle	Nathan Fillion - Richard Castle	Nathan Fillion - Richard Castle
Nathan Fillion - Richard Castle	Nathan Fillion - Richard Castle	Tamala Jones - Médico forente Lanie Parish
Tamala Jones - Médico forente Lanie Parish	Tamala Jones - Médico forente Lanie Parish	Ruben Santiago-Hudson – Capitan Roy Montgomery
Ruben Santiago-Hudson – Capitan Roy Montgomery	Ruben Santiago-Hudson – Capitan Roy Montgomery	Ruben Santiago-Hudson – Captain Roy Montgomery
Ruben Santiago-Hudson – Captain Roy Montgomery	Ruben Santiago-Hudson – Captain Roy Montgomery	Molly C. Quinn – Alexis Castle
Molly C. Quinn – Alexis Castle	Molly C. Quinn – Alexis Castle	Molly C. Quinn – Alexis Castle
Seamus Dever – Detective Kevin Ryan	Seamus Dever – Detective Kevin Ryan	Seamus Dever – Detective Kevin Ryan
Seamus Dever – Detective Kevin Ryan	Susan Sullivan – Martha Rodgers	Susan Sullivan – Martha Rodgers
Susan Sullivan – Martha Rodgers